Fig. 1From: DLEU1 promotes cell survival by preventing DYNLL1 degradation in esophageal squamous cell carcinomaUpregulated DLEU1 expression is associated with a poor prognosis in ESCC patients. A Volcano plots for differentially expressed lncRNAs in ESCC based on two publicly available microarray datasets: GSE53624 (left; n = 119 pairs) and GSE53622 (right; n = 60 pairs). B CCK-8 analysis of the relative growth rates of EC109 (left) and KYSE-410 (right) cells transfected with the indicated siRNA. C, D Comparison of DLEU1 expression between 119 (C) or 60 (D) ESCC and paired normal tissues. E Kaplan–Meier curves depicting the overall survival of ESCC patients with high or low DLEU1 expression. F Comparison of DLEU1 expression between tumor and adjacent normal tissues from the TCGA-ESCC dataset, which was obtained from the UCSC Xena platform. G Kaplan–Meier survival analysis according to DLEU1 expression levels in ESCC samples from the TCGA-ESCC dataset. H Representative images (left) and quantification (right) of DLEU1 expression in ESCC and matched nontumor tissues by ISH staining. Scale bars, 100 μm (left) and 50 μm (right). I GSEA of the indicated gene sets comparing samples with high and low DLEU1 expression in the GSE53624 dataset. NES, normalized enrichment score. Significance was assessed by the Wilcoxon matched-pairs signed rank test (C, D), log-rank test (E, G), or Mann–Whitney test (F, H). ***P < 0.001Back to article page