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Table 2 Cox regression analyses of RC, Lp(a), and hsCRP levels for predicting MACEs

From: Synergistic effect of the commonest residual risk factors, remnant cholesterol, lipoprotein(a), and inflammation, on prognosis of statin-treated patients with chronic coronary syndrome

Category

Model 1

HR (95% CI)

Model 2

HR (95% CI)

RC

 Low RC

1.00 (reference)

1.00 (reference)

 High RC

1.29 (1.03–1.61)*

1.47 (1.05–2.05)*

 Per 1-SD increase of RC

1.17 (1.05–1.32)†

1.26 (1.06–1.50)*

Lp(a)

 Low Lp(a)

1.00 (reference)

1.00 (reference)

 High Lp(a)

1.26 (1.01–1.57)*

1.40 (1.05–1.86)*

 Per 1-SD increase of LgLp(a)

1.16 (1.04–1.30)*

1.24 (1.07–1.44)*

HsCRP

 Low hsCRP

1.00 (reference)

1.00 (reference)

 High hsCRP

1.39 (1.11–1.75)†

1.27 (0.95–1.70)

 Per 1-SD increase of LghsCRP

1.17 (1.04–1.32)†

1.09 (0.94–1.26)

RC, Lp(a), and hsCRP

 Low RC-Low Lp(a)-Low hsCRP

1.00 (reference)

1.00 (reference)

 Low RC-High Lp(a)-Low hsCRP

1.22 (0.76–1.96)

1.09 (0.59–2.01)

 High RC-Low Lp(a)-Low hsCRP

1.19 (0.73–1.95)

1.00 (0.52–1.93)

 High RC-High Lp(a)-Low hsCRP

1.06 (0.63–1.80)

1.39 (0.74–2.61)

 Low RC-Low Lp(a)-High hsCRP

0.97 (0.57–1.67)

0.72 (0.36–1.46)

 Low RC-High Lp(a)-High hsCRP

1.45 (0.90–2.33)

1.30 (0.71–2.37)

 High RC-Low Lp(a)-High hsCRP

1.46 (0.94–2.27)

1.46 (0.82–2.61)

 High RC-High Lp(a)-High hsCRP

1.95 (1.29–2.95)†

1.99 (1.15–3.47)*

  1. Model 1 adjusted for age and sex; Model 2 adjusted for age, sex, smoking status, prior myocardial infarction, hypertension, diabetes, left ventricular ejection fraction, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol; creatinine, statin use and types at admission, and statin types on discharge
  2. HsCRP high-sensitivity C-reactive protein, Lp(a) lipoprotein(a), LgLp(a) log-transformed Lp(a), LghsCRP log-transformed hsCRP, MACEs major adverse cardiovascular events, RC remnant cholesterol
  3. *p < 0.05; †p < 0.01