Fig. 7
Overexpression of C2orf40 results in increased chemo-sensitivity and radio-sensitivity of NPC cells in vivo. A‒C An in vivo mouse xenograft tumor model was established by subcutaneous injection of HONE-1 cells into nude mice treated with PBS or cisplatin (4 mg/kg, once every 3 days). A Representative images of xenograft tumors resected from the xenograft model mice. The tumor volume (B) and tumor weight (C) were measured in xenograft tumors from nude mice. D‒F HONE-1 cells were subcutaneously injected into nude mice to establish the transplanted tumor model. When the tumor volume reached 150 ± 25 mm3, a local dose of 2.0 Gy was given 5 times. D Xenograft tumors were resected from mice after 21 days of injection of the cells. E Time–growth curves of tumor xenografts. F Weight of xenograft tumors harvested from mice. Data are presented as the mean ± SD. G Western blotting of the activation of PI3K/Akt/mTOR signaling pathway in xenografts. H Western blotting was used to detect the expression levels of cell cycle-related genes in xenografts. *P < 0.05, **P < 0.01, ***P < 0.001