From: Identifying the critical states and dynamic network biomarkers of cancers based on network entropy
Cancer | Gene | Type | Family | Relation with cancer progression |
---|---|---|---|---|
KIRC | CLIP4 | O-LNE | Regulatory | CLIP4 is involved in regulating the expression of several tumor-associated genes, and its expression is considered to stimulate tumor metastasis [13] |
CDCP1 | P-LNE | Enzyme | CDCP1 belongs to the tetraspanin web involved in tumor progression and metastasis [24] | |
LUSC | FGF11 | O-LNE | Signaling growth factor | FGF11 may be involved in the stabilization of capillary-like tube structures associated with angiogenesis and may act as a modulator of hypoxia-induced pathological processes such as tumorigenesis [14] |
AHNAK | P-LNE | Regulatory | AHNAK mediates negative regulation of cell growth and acts as novel tumor suppressor through potentiation of TGFB1 signaling [25] | |
STAD | ZNF350 | O-LNE | Transcription factor | ZNF350 has been reported to function as a tumor suppressor [26] |
ACE2 | P-LNE | Enzyme | ACE2 can affect macrophage expression of tumor necrosis factor (TNF-α) [15] | |
LIHC | IRF6 | O-LNE | Transcription factor | IRF6 suppresses tumorigenesis in stratified epithelia [27] |
TTK | P-LNE | Enzyme | TTK alone or in combination with other therapeutics may selectively kill tumor cells [16] |