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Table 1 Optimistic LNE (O-LNE) biomarkers and pessimistic LNE (P-LNE) biomarkers in KIRC, LUSC, STAD and LIHC

From: Identifying the critical states and dynamic network biomarkers of cancers based on network entropy

Cancer

Gene

Type

Family

Relation with cancer progression

KIRC

CLIP4

O-LNE

Regulatory

CLIP4 is involved in regulating the expression of several tumor-associated genes, and its expression is considered to stimulate tumor metastasis [13]

CDCP1

P-LNE

Enzyme

CDCP1 belongs to the tetraspanin web involved in tumor progression and metastasis [24]

LUSC

FGF11

O-LNE

Signaling growth factor

FGF11 may be involved in the stabilization of capillary-like tube structures associated with angiogenesis and may act as a modulator of hypoxia-induced pathological processes such as tumorigenesis [14]

AHNAK

P-LNE

Regulatory

AHNAK mediates negative regulation of cell growth and acts as novel tumor suppressor through potentiation of TGFB1 signaling [25]

STAD

ZNF350

O-LNE

Transcription factor

ZNF350 has been reported to function as a tumor suppressor [26]

ACE2

P-LNE

Enzyme

ACE2 can affect macrophage expression of tumor necrosis factor (TNF-α) [15]

LIHC

IRF6

O-LNE

Transcription factor

IRF6 suppresses tumorigenesis in stratified epithelia [27]

TTK

P-LNE

Enzyme

TTK alone or in combination with other therapeutics may selectively kill tumor cells [16]