Fig. 3

Gene expression distributions of non-mutated and mutated genes. Distribution of gene expression of non-mutated and mutated genes for our cell line data (a) and for patient data from TCGA-OV project (b). In blue is the expression distribution of top 50 non-mutated genes and in orange is the distribution of the top 50 mutated genes. Note that the expression of non-mutated genes is significantly higher than the expression of mutated genes in both the cell line and patient data. Distribution of gene expression of non-mutated genes (c) and mutated genes (d) in non-cancer cell lines and cancer lines. Note that there is no significant difference in gene expression difference between non-cancer and cancer cell lines in either mutated or non-mutated genes. The inset for each panel shows the cumulative density plots of the same data