Table 1 The inhibitory receptors of NK cells
From: Natural killer cells: a promising immunotherapy for cancer
Receptors | CD | Structure | Ligand | Signal molecule | Chromosome |
|---|---|---|---|---|---|
KIR2DL1 | CD158b | Ig monomer | HLA-C, N77/N80 | ITIM | 19q13.4 [97] |
KIR2DL2 | CD158b1 | Ig monomer | HLA-C, S77/N80 | ITIM | 19q13.4 [97] |
KIR2DL3 | CD158b2 | Ig monomer | HLA-C, S77/N80 | ITIM | 19q13.4 [97] |
KIR3DL1 | CD158e1 | Ig monomer | HLA-Bw4 | ITIM | 19q13.4 [105] |
KIR3DL2 | CD158k | Ig monomer | HLA-A3, HLA-A11 | ITIM | 19q13.4 [106] |
KIR2DL5A/B | CD158f | Ig monomer | Unknown | ITIM | 19q13.4 [107] |
LAIR-1 | CD305 | Ig monomer | Collagen | ITIM | 19q13.4 [107] |
LILRB1(ILT2) | CD85j | Ig monomer | HLA-I | ITIM | 19q13.4 [108] |
SIGLEC7(p75) | CDw328 | Ig monomer | Α-2,8 disialic acid | ITIM | 19q13.3 [109] |
CEACAM1 | CD66a | Ig monomer | CD66 | ITIM | 19q13.2 [107] |
CD94-NKG2A(KLRD1-KLRC1) | CD159a | C lectin heterodimer | HLA-E | ITIM | 12p13 [110] |
KLRG1 | Â | C lectin heterodimer | Cadherins | ITIM | 12p12-p13 [107] |
NKR-P1A(KLRB1) | CD161 | C lectin heterodimer | LLT-1 | ITIM | 12p13 [107] |
2B4 | CD224 | Ig monomer | CD48 | ITIM | 1q23.1 [107] |