Fig. 5
From: mTOR pathway gene mutations predict response to immune checkpoint inhibitors in multiple cancers
mTOR pathway mutations and immunological phenotype. The association of mutations in the 8-gene signature involved in mTOR pathway with overall immune cells infiltration, T cells infiltration, antigen presentation, and neoantigen production (A). A heatmap showed the fold changes of mRNA expression involved in different immune phenotype in the comparison of mutant-type versus wild-type patients (B). Specially, we showed the association of the mTOR pathway mutations with expression of chemokines (D) and immune checkpoints genes including PD1 and PDL1 (also termed CD274) (E) that were closely associated with ICI treatment efficacy. We also observed the change of immune cells infiltration induced by mTOR pathway mutations (C); **, < 0.01, ***, < 0.001