Fig. 4
From: mTOR pathway gene mutations predict response to immune checkpoint inhibitors in multiple cancers
Interaction with TMB and survival. The association of the mutations in the 8-gene signature with TMB in 5646 patients from MSKCC study (A) and the validation in 10,163 patients from TCGA database (B). In discovery stage of 1661 ICI-treated patients, we showed the survival comparison of mutant-type versus wild-type patients in presence of low TMB (n = 1173, C) and high TMB (n = 488, D) by Kapan-Meier curves and multivariate Cox regression. The survival interaction with TMB were further validated in validation stage of 327 low-TMB (E) and 155 high-TMB patients (F) by Kapan-Meier curves and multivariate RMST analysis. To alleviate the limited statistical power induced by subgroup stratification, we pooled the adjusted RMST results of the two stages using meta-analysis method in low-TMB patients (G) and high-TMB patients (H). We also combined the available samples in the two stages to associate the mutation states of the 8-gene signature with treatment response rate (I) and DCB rate (J)