From: The progression rate of spinocerebellar ataxia type 3 varies with disease stage
 | LM1 | LM2 | LM3 | LM4 | QM1 | PM1 | PM2 | PM2c | PM3 | PM3c | PM4 | PM4c |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Parameter estimates of fixed effects | ||||||||||||
 Intercept | 2.067 (1.309) P = 0.115 | 44.448 (24.183) P = 0.067 | − 16.464 (5.448) P = 0.003 | − 60.517 (38.837) P = 0.120 | 10.726 (1.915) P < 0.001 | 36.746 (1.955) P < 0.001 | − 59.997 (35.214) P = 0.089 | − 62.620 (31.899) P = 0.050 | 35.501 (8.876) P < 0.001 | 36.472 (8.274) P < 0.001 | − 217.508 (57.354) P < 0.001 | − 216.416 (49.701) P < 0.001 |
 dt | 2.744 (0.154) P < 0.001 | − 7.940 (2.670) P = 0.003 | 4.050 (0.702) P < 0.001 | − 12.590 (4.346) P = 0.005 | 1.199 (0.280) P < 0.001 | – | – | – | – | – | – | – |
 dt2 | – | – | – | – | 0.069 (0.009) P < 0.001 | – | – | – | – | – | – | – |
 d1 | – | – | – | – | – | 2.445 (0.185) P < 0.001 | − 7.264 (3.305) P = 0.028 | − 7.582 (2.771) P = 0.006 | 3.671 (0.817) P < 0.001 | 3.787 (0.723) P < 0.001 | − 9.944 (5.672) P = 0.080 | − 9.814 (4.606) P = 0.034 |
 d2 | – | – | – | – | – | 3.547 (0.312) P < 0.001 | − 7.516 (5.989) P = 0.210 | − 6.604 (2.785) P = 0.018 | 5.323 (1.582) P < 0.001 | 4.878 (0.765) P < 0.001 | − 8.414 (9.030) P = 0.352 | − 8.745 (4.618) P = 0.059 |
 CAGexp | – | − 0.623 (0.356) P = 0.084 | – | 0.562 (0.485) P = 0.250 | – | – | 1.429 (0.519) P = 0.007 | − 0.460 (0.328) P = 0.164 | – | – | 3.195 (0.716) P < 0.001 | 0.970 (0.449) P = 0.034 |
 dt*CAGexp | – | 0.157 (0.039) P < 0.001 | – | 0.205 (0.054) P < 0.001 | – | – | – | 0.148 (0.041) P < 0.001 | – | – | – | 0.171 (0.058) P = 0.003 |
 d1*CAGexp | – | – | – | – | – | – | 0.144 (0.049) P = 0.003 | – | – | – | 0.171 (0.070) P = 0.016 | – |
 d2*CAGexp | – | – | – | – | – | – | 0.162 (0.088) P = 0.067 | – | – | – | 0.172 (0.113) P = 0.128 | – |
 AOga | – | – | 0.446 (0.128) P < 0.001 | 0.590 (0.184) P = 0.002 | – | – | – | – | 0.026 (0.206) P = 0.898 | 0.424 (0.112) P < 0.001 | 0.895 (0.271) P = 0.002 | 0.680 (0.168) P < 0.001 |
 dt*AOga | – | – | − 0.032 (0.016) P = 0.055 | 0.025 (0.021) P = 0.232 | – | – | – | – | – | − 0.032 (0.017) P = 0.055 | – | 0.015 (0.022) P = 0.513 |
 d1*AOga | – | – | – | – | – | – | – | – | − 0.030 (0.019) P = 0.123 | – | 0.018 (0.027) P = 0.517 | – |
 d2*AOga | – | – | – | – | – | – | – | – | − 0.043 (0.037) P = 0.251 | – | 0.005 (0.047) P = 0.917 | – |
Fit statistics | ||||||||||||
 AIC | 4019.470 | 4013.763 | 4021.004 | 4005.769 | 3984.778 | 3945.904 | 3947.395 | 3942.736 | 3952.541 | 3946.137 | 3939.014 | 3928.450 |
 BIC | 4046.163 | 4049.328 | 4056.57 | 4050.194 | 4015.909 | 3990.377 | 4005.148 | 3996.066 | 4010.294 | 3999.467 | 4010.018 | 3990.623 |
 logLik | − 2003.735 | − 1998.881 | − 2002.502 | − 1992.884 | − 1985.389 | − 1962.952 | − 1960.697 | − 1959.368 | − 1963.270 | − 1961.069 | − 1953.507 | − 1950.225 |
 Conditional R2 | 0.970 | 0.971 | 0.971 | 0.972 | 0.978 | 0.979 | 0.979 | 0.979 | 0.979 | 0.979 | 0.980 | 0.980 |
 Marginal R2 | 0.479 | 0.540 | 0.480 | 0.623 | 0.488 | 0.517 | 0.575 | 0.575 | 0.516 | 0.517 | 0.641 | 0.643 |
 P-value in ANOVA | – | Pa = 0.008 | Pa = 0.292 | Pa < 0.001 | Pa < 0.001 Pb < 0.001 | Pa < 0.001 | Pa = 0.212 Pb < 0.001 | Pb = 0.028 Pc < 0.001 | Pb = 0.888 Pc < 0.001 | Pb = 0.152 Pc < 0.001 | Pb = 0.004 Pc < 0.001 | Pb < 0.001 Pc < 0.001 |