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Table 1. Characteristics of the 8 studies on physical activity and digestive system cancer risk included in the meta-analysis

From: Association between physical activity and infertility: a comprehensive systematic review and meta-analysis

Authors, year Gender Region Subjects Cases Relative Risk (95%CI) for high vs low PA Relative Risk (95%CI) forhigh vs moderate PA Relative Risk (95%CI) for moderate vs low PA Low PA defined by Moderate PA defined by High PA defined by Adjustment factors (excluding age ,sex)
Cohort studies
 Esmaeilzadeh et al. 2013 Women Iran 2162 1081 0.77 (0.50, 1.19) 0.96 (0.56, 1.56) 0.80 (0.76, 0.83) Low PA Moderate PA High PA None
 Lei et al. 2015 Women China 367 310 0.38 (0.11, 1.29) None None Non-exercise None ≥ 180 min/week Adjusted on occupational exposure, family income, menstruation,Chinese herbal medicine use, alcohol consumption
 Cong et al. 2016 Women China 670000 5131 0.58 (0.42, 0.81) 2.32 (1.25, 4.20) 0.25 (0.10, 0.65) Light exercise Regular PA Heavy exercise Adjusted for age at marriage, marriage age limit, weight andheight
 Gudmundsdottir et al. 2009 Women Norway 7774 3887 0.60 (0.30, 1.2) 1.67 (1.53, 1.67) 0.90 (0.60, 1.50) Low PA Medium PA High PA Adjusted for smoking and marital status
 Rich-Edwards et al. 2002 Women England 26125 830 0.63 (0.44, 0.91) None None < 30 min/week None ≥ 420 min/week Adjusted for time spent in moderate activity, recency of oralcontraceptive use, intake of alcohol, and cigarette smoking
 Läänelaid et al. 2021 MenWomen Estonia 64 64 128 0.94 (0.66, 1.35) 0.43 (0.30, 0.62) 1.37 (1.33, 1.41) 1.11 (1.08, 1.13) 0.69 (0.49,0.96) 0.39 (0.27, 0.55) Sedentary Moderate PA Vigorous PA Adjusted for age and registered time.
Case-control studies
 Forman et al. 1994 Men England 1587 794 0.54 (0.32, 0.90) None None Non-exercise None ≥ 900 min/week Adjusted for undescended testis and inguinal hernia diagnosed < 15 years
 Green et al. 1986 Women American 200 100 0.90 (0.20, 3.60) None None Non-exercise None ≥ 150 min/week Adjusted for race, census tract of residence, Reference year, parity, and times married.
Foucaut et al. 2019 MenWomen French 151151 7980 0.45 (0.22, 0.94) 0.63 (0.29, 1.37) None None < 150 min/week None ≥ 150 min/week Adjusted for educational level and for all variables of the table
Dhair et al. 2020 Women Palestine 320 160 0.32 (0.17, 0.63) 0.75 (0.42, 1.35) 0.43 (0.40, 0.46) Low PA Moderate PA High PA None