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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: miR-18a-5p derived from mesenchymal stem cells-extracellular vesicles inhibits ovarian cancer cell proliferation, migration, invasion, and chemotherapy resistance

Fig. 4

miR-18a-5p knockdown partially annulled the inhibition of EVs on OC cell proliferation, migration and invasion. A EVs were treated differently and miR-18a-5p expression in EVs was detected by RT-qPCR; B Size distribution of EVs was analyzed by NTA; C–E miR-18a-5p expression was measured via RT-qPCR; F Cell viability was assessed using MTT assay; G, H Migration and invasion of OC cells were evaluated by Transwell assays. Cell experiments were replicated 3 times. Data were presented as mean ± SD. Data were analyzed by two-way (panel F) or one-way ANOVA (panels A/C/D/E/G/H).One-way ANOVA was employed for comparisons between groups and Tukey's multiple comparisons test was performed for the post hoc test. **P < 0.01, ***P < 0.001

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