Fig. 3From: miR-18a-5p derived from mesenchymal stem cells-extracellular vesicles inhibits ovarian cancer cell proliferation, migration, invasion, and chemotherapy resistancemiR-18a-5p was downregulated in OC. A Heatmap of significantly downregulated miRNAs in OC microarray GSE161784 (abscissa: sample name; ordinate: miRNA name; small square: the expression level of a miRNA in a sample; upper right histogram: color scale); B Intersection of significantly reduced miRNAs in chemotherapy-resistant samples and miRNAs expressed in hMSC-EVs in the EVmiRNA database was obtained, with the middle as the intersection; C, D Expression of miR-18a-5p was determined by RT-qPCR; E Prognosis of OC patients with low and high miR-18a-5p expression was assessed using Kaplan–Meier survival analysis. Data analysis was performed using one-way ANOVA (panel C) with Tukey's multiple comparisons test for the post hoc test. The independent sample t test was used for comparisons between the two groups (panel D). ***P < 0.001Back to article page