Fig. 3

Oncoplots for drug-sensitive and drug-resistant (A) HR + samples, (B) HER2 + samples, and (C) TNBC samples. The green bars below the heatmap indicate samples collected from patients who are sensitive to treatment, while the orange bars indicate samples collected from patients who are resistant to treatment. Different colours of squares denote different types of mutations. Red represents SNVs/Indels, blue represents amplifications, and green represents deletions. Survival analyses of OS (D) between patients with or without TP53 mutations and (E) between patients with or without PIK3CA mutations. F Comparison of ctDNA fractions among the three IHC subtypes. The black lines represent the median of each group. HR + , hormone receptor-positive; HER2 + , human epidermal growth factor receptor 2-positive; TNBC, triple-negative breast cancer; SNVs, single nucleotide variations; Indels, insertions and deletions; OS, overall survival; ctDNA, circulating tumour DNA; IHC, immunohistochemistry