Fig. 2

Concordance analysis of mutations between plasma and tissue samples. Concordance of (A) SNVs and (B) CNVs between tissue samples and plasma ctDNA. In the matrices, the top bar charts depict the number of mutations. The text below represents patient identities, and the text on the left represents gene names. Coloured triangles in the squares indicate mutations. If a square was filled with two coloured triangles, the same mutation was detected in the corresponding patient's plasma and tissue. Overlapping (C) PIK3CA SNVs, (D) TP53 SNVs, and (E) ERBB2 CNVs between tissue and plasma ctDNA. SNVs, single nucleotide variations; CNVs, copy number variations; ctDNA, circulating tumour DNA