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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Heat shock protein A4 ablation leads to skeletal muscle myopathy associated with dysregulated autophagy and induced apoptosis

Fig. 1

Up-regulation of HSPA4 in regenerating myocyte and differentiating myoblast. A mRNA expression of Hspa4, evaluated by real time PCR, in tibialis anterior after cardiotoxin injection (n = 3/time point). B Western blotting of HSPA4 protein after cardiotoxin injection (left panels) and densitometry measurement (right panel) (n = 3/time point). C Representative immunostaining of WT tibialis anterior sections for HSPA4 protein at 5 days after vehicle- and cardiotoxin-treatment. D Immunoblots (left panels) and densitometry analysis (right panel) of HSPA4 levels in C2C12 during proliferation in growing medium (GM) and differentiation for 1–4 days in differentiation medium (DM1-DM4) (n = 3/ time point). Data are expressed as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 vs. corresponding controls, two-tailed unpaired Student's t-test

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