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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Extracellular vesicles from the inflammatory microenvironment regulate the osteogenic and odontogenic differentiation of periodontal ligament stem cells by miR-758-5p/LMBR1/BMP2/4 axis

Fig. 4

EVs promoted PDLSCs osteogenic and odontogenic differentiation with no significant intergroup proliferative difference. A ALP activity of PDLSCs induced by different concentrations of EV for 7 days. B CCK-8 revealed the impact on cell proliferation from DPSC-EV and iDPSC-EV. C The relative mRNA levels of ALP, OSX, and DSPP after induced by EV at different time points. D The western blot bands showed EV-mediated expression of ALP, OSX, and DSPP. E The histogram showed the relative quantitative analysis of western blot. F Result of quantification of ARS. G Result of ALP staining. H Result of ARS staining. n = 3, **P < 0.01, *P < 0.05. Scale bar, 100 μm

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