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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolism

Fig. 2

CSE-induced mitochondrial oxidative stress dysregulated lipid metabolism to activate LF. A Nile Red staining was performed to show lipid content in cells treated as indicated. B The effect of CSE on protein level of CPT1a and PPARα which were related with FAO. C The effect of PPARα activator Feno on CPT1a level. D Western blot to determine the level of Collagen I and α-SMA. E The role of MitoQ in CPT1a and PPARα expression. F Nile Red staining. G Western blot analysis for Collagen I and α-SMA expression. *p < 0.05 versus control, #p < 0.05 versus CSE, &p < 0.05 versus CSE + Feno or CSE + MitoQ. Feno fenofibrate, ETO etomoxir, OA oleic acid

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Journal of Translational Medicine

ISSN: 1479-5876

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