Fig. 3
From: Inhibition of NOS1 promotes the interferon response of melanoma cells
NOS1 regulated gene expression related to innate immune response. A Schematic representation of the experimental design. B KEGG analysis showed that the gene number and pathways enriched in interferon stimulating genes (ISGs) were increased by NOS1 inhibition (Red / Blue for NPLA / control group). C Schematic diagram shows the up regulation of innate immune pathways in RNA-seq data with NOS1 inhibitor (N-PLA). The expression of key components of JAK-STAT and Toll-like pathway (TLR3, MYD88, STAT1/2, OAS1, AIM2, NOD2 and GBP3/5) and downstream signal events were increased by NOS1 inhibition. (Red and Green for up and down-regulation respectively). D Log2FC of downstream genes were increased by NOS1 inhibition. (Red and Green for up and down-regulation respectively)