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Table 1 Baseline characteristics between groups before and after PSM

From: Association between early ondansetron administration and in-hospital mortality in critically ill patients: analysis of the MIMIC-IV database

Variables Entire cohort
(n = 51,342)
SMD PSM cohort
(n = 10,724)
SMD
Non-ondansetron (n = 45,980) Ondansetron
(n = 5362)
Non-ondansetron
(n = 5362)
Ondansetron
(n = 5362)
Age [median (IQR)] 64.7 (52.2,76.5) 59.6 (46.5,70.2) 0.165 64.1 (51.5,75.9) 64.6 (53.0,74.2) 0.006
Men, n (%) 26,146 (56.9) 2670 (49.8) 0.142 2699 (50.3) 2670 (49.8) 0.016
Ethnicity, n (%)    0.054    0.023
 Black 4352 (9.5) 402 (7.5)   493 (9.2) 402 (7.5)  
 White 31,023 (67.5) 3635 (67.8)   3451 (64.4) 3635 (67.8)  
 Hispanic 1598 (3.5) 190 (3.5)   215 (4.0) 190 (3.5)  
 Others 3604 (7.8) 449 (8.4)   477(8.9) 449 (8.5)  
Admission type, n (%)    0.201    0.006
 Medical/non-surgical 31,901 (69.4) 2794 (52.1)   3253 (60.7) 2794 (52.1)  
 Elective surgical 6678 (14.5) 1840 (34.3)   925 (17.3) 1840 (34.3)  
 Non-elective surgical 7401 (16.1) 728 (13.6)   1184 (22.1) 728 (13.6)  
Comorbidities at ICU admission, n (%)       
 Myocardial infarct 7307 (15.9) 872 (16.3) 0.010 863 (16.1) 872 (16.3) 0.023
 Congestive heart failure 11,196 (24.3) 970 (18.1) 0.154 930 (17.3) 970 (18.1) 0.002
 Peripheral vascular disease 5067 (11.0) 549 (10.2) 0.025 547 (10.2) 549 (10.2) 0.017
 Cerebrovascular disease 7249 (15.8) 853 (15.9) 0.004 870 (16.2) 853 (15.9) 0.011
 Dementia 1715 (3.7) 109 (2.0) 0.102 100 (1.9) 109 (2.0) 0.025
 Chronic pulmonary disease 10,987 (23.9) 1044 (19.5) 0.108 1045 (19.5) 1044 (19.5) 0.006
 Rheumatic disease 1487 (3.2) 173 (3.2) 0.001 148 (2.8) 173 (3.2) 0.001
 Peptic ulcer disease 1302 (2.8) 121 (2.3) 0.037 108 (2.0) 121 (2.3) 0.023
 Liver disease 6741 (14.6) 651 (12.1) 0.070 637(19.9) 651 (12.1) 0.002
 Diabetes with CC 13,764 (29.9) 16,178 (30.1) 0.097 1600 (29.8) 1618 (30.1) 0.009
 Paraplegia 2431 (5.3) 220 (4.1) 0.056 227 (4.2) 220 (4.1) 0.016
 Renal disease 8207 (17.8) 786 (14.7) 0.087 724 (13.5) 786 (14.7) 0.014
 Malignant cancer 5826 (12.7) 603 (11.2) 0.044 614 (11.5) 603 (11.2) 0.002
 Metastatic solid tumor 2802 (6.1) 304 (5.7) 0.018 325 (6.1) 304 (5.7) 0.011
 AIDS 264 (0.6) 15 (0.3) 0.045 23 (0.4) 15 (0.3) 0.007
Need of support in the first 24 h, n (%)       
 Vasopressors 12,606 (27.4) 1735 (32.4) 0.108 1764 (32.9) 1735 (32.4) 0.005
 MV 12,044 (26.2) 1499 (28.0) 0.040 1504 (28.0) 1499 (28.0) 0.001
 RRT 877 (1.9) 93 (1.7) 0.013 90 (1.7) 93 (1.7) 0.008
ICU types, n (%)    0.122    0.009
 CCU 5539 (12.0) 302 (5.6)   588 (11.0) 302 (5.6)  
 SICU 7307 (15.9) 603 (11.2)   915 (17.1) 603 (11.2)  
 NSICU 1006 (2.2) 298 (5.6)   114 (2.1) 298 (5.6)  
 CVICU 7628 (16.6) 1744 (32.5)   1102 (20.6) 1744 (32.5)  
 TSICU 6111 (13.3) 616 (11.5)   791 (14.8) 616 (11.5)  
 MICU 9140 (19.9) 595 (11.1)   865 (16.1) 595 (11.1)  
 MICU/SICU 7779 (16.9) 738 (13.8)   816 (15.2) 738 (13.8)  
Primary diagnosis, n (%)    0.051    0.007
 Circulatory system 16,820 (36.6) 2469 (46.0)   2130 (39.7) 2469 (46.0)  
 Injury or poisoning 7416 (16.1) 648 (12.1)   980 (18.3) 648 (12.1)  
 Infectious diseases 4532 (9.9) 347 (6.5)   452 (8.4) 347 (6.5)  
 Digestive system 4247 (9.2) 471 (8.8)   429 (8.0) 471 (8.8)  
 Respiratory system 3183 (6.9) 149 (2.8)   300 (5.6) 149 (2.8)  
 Immunity diseases 1288 (2.8) 165 (3.1)   151 (2.8) 165 (3.1)  
 Nervous system 1166 (2.5) 150 (2.8)   121 (2.3) 150 (2.8)  
 Genitourinary system 743 (1.6) 65 (1.2)   46 (0.9) 65 (1.2)  
Severity of illness       
 SOFA score [median (IQR)] 4 (3,10) 4 (3,9) 0.144 4 (3,9) 4.(3,10)  
 SAPS II score [median (IQR)] 33 (13,50) 32 (12,48) 0.051 32 (12,48) 32 (12,49)  
Outcome       
 In-hospital mortality, n (%) 3481 (7.6) 229 (4.3)   301 (5.6) 229 (4.3)  
  1. PSM: propensity acore matching; ICU: intensive care unit; AIDS: acquired immune deficiency syndrome; MV: mechanical ventilation; RRT: renal replacement therapy; CCU: coronary care unit; SICU: surgical intensive care unit; NSICU: neuro surgical intensive care unit; CVICU: cardiac vascular intensive care unit; TSICU: trauma surgical intensive care unit; MICU: medical intensive care unit; IQR: interquartile range; SOFA: sequential organ failure assessment; SAPS II: Simplified Acute Physiology Score II