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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: CDK4/6 inhibitors sensitize gammaherpesvirus-infected tumor cells to T-cell killing by enhancing expression of immune surface molecules

Fig. 6

Effect of CDK4/6 inhibitors on viral and interferon-related cellular genes. KSHV genes (a), EBV genes (b), and cellular genes related to interferon pathway (IFN alpha, IFNbeta, IFNgamma, ERV3-1, DNMT1, DDX58, IFNL2, and selected interferon-stimulated genes) (c) in cells treated either with ethanol control (0 μM Abe) or 1 μM Abe for 24 h. Total RNA was extracted from whole cell lysates and expression of specific genes was assayed by RT-qPCR. mRNA levels were normalized to β-Actin and compared to those in control cells. Shown are average fold changes of mRNA levels in Abe-treated cells relative to ethanol-treated control cells from 3 independent experiments. Error bars represent standard deviations from 3 independent experiments. Statistically significant differences (*p ≤ 0.05, **p ≤ 0.01, ns not significant, paired 2-tailed t-test) between control and Abe-treated cells are indicated

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Journal of Translational Medicine

ISSN: 1479-5876

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