Fig. 4

CDK4/6 inhibitors increase mRNA expression of MHC-I, ICAM-1, B7-2, and PD-L1 in KSHV⁺ cells and EBV⁺ cells. JSC-1 (a), BCBL-1 (b), Akata (c), and Raji (d) cells were treated with 1 μM abemaciclib, or with RPMI medium control for 24 h or 48 h. Total RNA was extracted and analyzed for mRNA expression of MHC-I, ICAM-1, B7-2 and PD-L1 using realtime qPCR. Results shown are mean fold changes relative to untreated cells from 3 experiments. Error bars represent standard deviations from the 3 experiments