Fig. 1
Overview of m6A RNA methylation regulators in the single-cell data for colorectal cancer. A The overall design of the present study and the data sourced from the SMC dataset (GSE132465). B Cell type annotations by using the Seurat t-distributed stochastic neighbor embedding (t-SNE) plot of 65,362 cells; C Cell–Cell communications between main six cell types by Cell chat analysis. D Average expression of m6A RNA methylation regulators in 65,362 cells according to different clinical variables in the SMC dataset containing cell types, including class types (normal vs. tumor), MSI (MSI-H vs. MSS), Age (old vs. young), Stage (I, IIA, IIIA, IIIB IIIC, and IVA), and Gender (female vs. male) by using z-score. E Heatmap distribution of m6A RNA methylation regulators in B cells, epithelial cells, mast cells, myeloid cells, stromal cells, and T cells. F NMF cluster by using the 23 m6A regulators RNA expression respectively for the main four types of TME cells (CAFs, Macrophage cells, T cells, and B cells) in the scRNA data