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Table 3. Identification of hub genes by PPI network

From: Identification of invasion-metastasis associated MiRNAs in gallbladder cancer by bioinformatics and experimental validation

Up-regulated miRNAs Down-regulated miRNAs
Gene Degree Gene Degree
MAPK1 34 AKT1 76
PTEN 27 VEGFA 68
SYK 25 MAPK1 65
TAF1 23 EGFR 63
CDKN1A 22 MYC 59
POLR2E 21 IL6 57
PRKCA 21 BCL2 52
CDK4 19 ACTB 44
SH3GL1 19 SMAD4 43
DNAJC10 18 ESR1 42
  1. PPI protein–protein interaction