Fig. 1

Bioinformatics analysis of lncRNAs that are potentially associated with GC metastasis. A The Venn diagram of overlapping differentially expressed lncRNAs among TCGA and GEPIA datasets. Venn diagrams shows differentially expressed genes shared by TCGA and GEPIA. A total of 5 lcnRNAs were identified in the intersection. B GO enrichment analysis of the up-regulated genes in metastatic GC. GO enrichment analysis was performed on the up-regulated genes in metastatic GC using DAVID. Several transcriptional regulation pathways such as GO: 0006351—transcription, DNA-templated and GO: 0006355—regulation of transcription, DNA-templated, were prominently involved. C Putative site of POU2F1 was predicted on LINC01564 promoter sequence. D Putative binding site of POU2F1 3′UTR and LINC01564. E Using data from TCGA database, we analyzed the correlation between POU2F1 and lncRNA LINC01564 in patients with or without GC metastasis