Skip to main content
Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Angiopoietin2-mediated caveolin1 phosphorylation regulating transcytosis of renal tubular epithelial cell contributes to the occurrence of albuminuria under high glucose exposure

Fig. 7

Schematic model for ANGPT2-mediated CAV1 phosphorylation in the inhibition of albumin transcytosis. Here we depict the model for albumin transcytosis under the regulation of ANGPT2 and CAV1. A ANGPT2/P- CAV1 signaling pathways involved in albumin transcytosis in HK-2 cells in HG. B Summary chart of this research findings. Following HG exposure, ANGPT2 is upregulated, which lead to increased CAV1 phosphorylation in tubular cells. CAV1 phosphorylation inhibited the albumin transcytosis. Angiopoietin2-mediated Caveolin1 phosphorylation blocked albumin transcytosis, which participates in the occurrence of diabetic kidney disease (DKD)-related albuminuria

Back to article page

Journal of Translational Medicine

ISSN: 1479-5876

Contact us