From: Early and strong antibody responses to SARS-CoV-2 predict disease severity in COVID-19 patients
Antigen | Mild, % | Moderate, % | Severe, % | Total, % | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
IgG | IgA | IgE | IgG | IgA | IgE | IgG | IgA | IgE | IgG | IgA | IgE | |
Full-lenght proteins or subunits | ||||||||||||
SFL3 | 94.7 | 16.7 | 66.7 | 100 | 38.5 | 92.3 | 100 | 54.5 | 90 | 97.3 | 30.1 | 79.7 |
SFL | 97.4 | 25 | 12.1 | 100 | 42.3 | 50 | 100 | 54.5 | 60 | 98.7 | 35.6 | 33.3 |
SRBD | 92.1 | 22.2 | 0 | 100 | 42.3 | 3.85 | 100 | 63.6 | 10 | 96 | 35.6 | 2.9 |
S1sub | 89.5 | 22.2 | 0 | 100 | 42.3 | 34.6 | 100 | 63.6 | 20 | 94.7 | 35.6 | 15.9 |
S2sub | 100 | 25 | 3.03 | 100 | 42.3 | 19.2 | 100 | 54.5 | 20 | 100 | 35.6 | 11.6 |
NFL | 94.7 | 19.4 | 66.7 | 100 | 46.2 | 96.2 | 100 | 45.5 | 100 | 97.3 | 32.9 | 82.6 |
MFL | 84.2 | 13.9 | 0 | 100 | 30.8 | 23.1 | 100 | 45.5 | 0 | 92 | 24.7 | 8.7 |
Predicted epitopes or protein fragments | ||||||||||||
S1 | 5.26 | 0 | 0 | 7.69 | 0 | 0 | 27.3 | 0 | 0 | 9.33 | 0 | 0 |
S2 | 31.6 | 0 | 0 | 26.9 | 0 | 0 | 72.7 | 0 | 0 | 36 | 0 | 0 |
S3 | 26.3 | 0 | 0 | 26.9 | 0 | 0 | 54.5 | 0 | 0 | 30.7 | 0 | 0 |
S4 | 5.26 | 0 | 0 | 15.4 | 0 | 0 | 36.4 | 0 | 0 | 13.3 | 0 | 0 |
S5 | 34.2 | 0 | 0 | 23.1 | 0 | 0 | 36.4 | 0 | 0 | 30.7 | 0 | 0 |
S6 | 13.2 | 0 | 0 | 15.4 | 0 | 3.85 | 0 | 0 | 0 | 12 | 0 | 1.45 |
S7 | 42.1 | 2.78 | 15.2 | 69.2 | 0 | 34.6 | 90.9 | 0 | 30 | 58.7 | 1.37 | 24.6 |
S8 | 13.2 | 0 | 0 | 15.4 | 3.85 | 0 | 18.2 | 0 | 0 | 14.7 | 1.37 | 0 |
S9 | 28.9 | 0 | 0 | 26.9 | 0 | 0 | 45.5 | 0 | 0 | 30.7 | 0 | 0 |
S10 | 15.8 | 0 | 0 | 15.4 | 0 | 0 | 18.2 | 0 | 0 | 16 | 0 | 0 |
S11 | 0 | 0 | 0 | 7.69 | 0 | 7.69 | 18.2 | 0 | 0 | 5.33 | 0 | 2.9 |
M1 | 18.4 | 0 | 0 | 38.5 | 0 | 0 | 54.5 | 0 | 0 | 30.7 | 0 | 0 |
N1 | 28.9 | 0 | 0 | 30.8 | 3.85 | 0 | 54.5 | 0 | 0 | 33.3 | 1.37 | 0 |
N2 | 42.1 | 0 | 0 | 53.8 | 0 | 0 | 63.6 | 0 | 0 | 49.3 | 0 | 0 |
NSP1 | 36.8 | 0 | 0 | 15.4 | 0 | 0 | 36.4 | 0 | 0 | 29.3 | 0 | 0 |
NSP2 | 7.89 | 0 | 0 | 11.5 | 0 | 0 | 27.3 | 0 | 0 | 12 | 0 | 0 |
NSP3 | 2.63 | 0 | ND | 11.5 | 0 | ND | 9.09 | 0 | ND | 6.67 | 0 | ND |
NSP4 | 2.63 | 0 | ND | 3.85 | 0 | ND | 0 | 0 | ND | 2.67 | 0 | ND |
NSP5 | 31.6 | 0 | ND | 34.6 | 0 | ND | 45.5 | 0 | ND | 34.7 | 0 | ND |
ORF3b | 2.63 | 0 | ND | 3.85 | 0 | ND | 18.2 | 0 | ND | 5.33 | 0 | ND |
ORF8 | 7.89 | 0 | ND | 7.69 | 0 | ND | 18.2 | 0 | ND | 9.33 | 0 | ND |
ORF8_1 | 0 | 0 | ND | 0 | 0 | ND | 0 | 0 | ND | 0 | 0 | ND |
ORF8_2 | 5.26 | 0 | ND | 15.4 | 0 | ND | 27.3 | 0 | ND | 12 | 0 | ND |