Fig. 6
From: SORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia
SORBS2 siRNA inhibits ROS production. THP-1 derived macrophages were pretreated with Si-SORBS2 or Si-NC for 24 h and then stimulated with OxLDL (50 µg/mL) for 24 h. A ROS production was detected by flow cytometry. B Densitometric analysis was used to quantify the levels of ROS production (n = 3). C Relative fluorescence intensity was also measured using a fluorescence microplate reader (n = 5). *** P < 0.001 and **** P < 0.0001 compared with the control group (no OxLDL treatment); ###P < 0.001 and ####P < 0.0001 compared with the corresponding controls (OxLDL at 50 µg/mL)