Fig. 2

Vascular morphology in patients with CVST and animal models. a MRV reconstruction in the healthy control group showing no abnormalities in vascular anatomy. b MRV reconstruction in patients with CVST showing filling defects in the SSS, right transverse sinus and sigmoid sinus (white arrows). c, d T2WI and MRA maps. c No abnormality of cerebral vascular anatomy in the sham group. d In the model group, the SSS is filled with swellable rubber, without blood flow (yellow arrows), and a high-signal area can be observed near the SSS (red arrows). e, f Microscope photographs and CBF maps obtained via LSCI. e In the sham group, all veins are normal. f In the model group, the parasagittal veins are distorted and tortuous, and anastomotic pathways have formed between the distorted veins (black arrows). Red to blue color bars on the right side represent blood flow from high to low. Scale bar = 1 mm. CVST: cerebral venous sinus thrombosis; MRV: magnetic resonance venography; T2WI: T2-weighted imaging; MRA: magnetic resonance angiography; SSS: superior sagittal sinus; CBF: cerebral blood flow; LSCI: laser-speckle contrast imaging