Table 2 Target molecules of exosomal circRNAs and consequences of their targeting in malignant tumors

LSCC

circRASSF2

miRNA-302b-3p/IGF-1R

Proliferation

[23]

OSCC

circGDI2

miR-424-5p/SCAI

Progression

[101]

circ_0000199

miR-145-5p, miR-29b-3p

Proliferation, apoptosis

[100]

NPC

circMYC

miR-20b-5p, let-7e-3p

Proliferation, radiosensitivity

[102]

PTC

circFNDC3B

miR-1178/TLR4

Proliferation, apoptosis

[103]

ESCC

hsa-circ-0048117

miR-140

Invasion, metastasis

[64]

hsa_circ_0026611

Wnt/β-catenin

Lymph node metastasis

[63]

CRC

circSLC7A6

CXCR5

Proliferation, invasion, apoptosis

[121]

circ-133

miR-133a/GEF-H1/RhoA

Metastasis

[120]

circ-HMGCS1

miR-34a-5p/SGPP1

Proliferation, invasion, apoptosis

[119]

circ_IFT80

miR-296-5p/MSI1

Tumorigenesis, radiosensitivity

[105]

circLONP2

miR-17

Invasion, metastasis

[104]

circ_0067835

miR-296-5p/IGF1R

Radiosensitivity

[47]

circIFT80

miRNA-1236-3p/HOXB7

Proliferation

[26]

circFMN2

miRNA-1182

Proliferation

[27]

circ_0000338

longevity regulating pathway

Resistance

[50]

ciRS-122

miRNA-122/M2-PK

Resistance

[51]

circ_0000677

Wnt/β-catenin

Invasion, metastasis

[45]

HCC

circRNA_100284

miR217

Proliferation, cell cycle

[24]

circUHRF1

PD1

Resistance

[110]

circ_0061395

miR-877-5p/PIK3R3

Progression

[109]

circ-0004277

ZO-1, EMT

Invasion

[36]

circPTGR1

miR449a-MET

Metastasis

[35]

circRNA-100,338

HUVECs

Metastasis

[34]

circDB

miRNA-34a/USP7/Cyclin A2

Proliferation

[25]

circPTGR1

miRNA449a/MET

Metastasis

[35]

circ_100338

HUVECs

Metastasis

[34]

circCdr1as

miRNA-1270/AFP

Invasion, metastasis

[122]

Cholangiocarcinoma

circ_0000284

miRNA-637/LY6E

Invasion, metastasis

[37]

GBM

circSMARCA5

RBP SRSF1

Metastasis

[117]

Glioma

circRNA 0001445

miRNA-127-5p/SNX5

Progression

[116]

circ-HIPK3

miR-421/ZIC5

TMZ resistance

[85]

PC

hsa_circ_0000069

STIL

Tumorigenesis

[107]

circ_0030167

miR-338-5p/wif1/Wnt 8/β-catenin

Proliferation, invasion, metastasis

[106]

circ-PDE8A

miR-338/MACC1/MET

Invasion

[39]

circZNF91

miR-23b-3p

GEM resistance

[52]

circPED8A

miRNA-338/MACC1/MET

Invasion, metastasis

[52]

circIARS

miRNA-12/RhoA

Invasion, metastasis

[38]

PDAC

circ-IRAS

endothelial monolayer permeability

Metastasis

[38]

TNBC

circPSMA1

miR-637/Akt1/β-catenin (cyclin D1)

Tumorigenesis, metastasis

[114]

Breast cancer

circHIF1A

miR-580-5p

Proliferation; stemness

[115]

circ_UBE2D2

miR-200a-3p

Tamoxifen resistance

[55]

NSCLC

circFARSA

PTEN/PI3K/AKT

Metastasis

[83]

circRNA_102481

microRNA-30a-5p/ROR1

EGFR-TKI resistance

[73]

hsa_circ_0002130

miR-498

Osimertinib resistance

[73]

hsa_circ_0014235

miR-520a-5p/CDK4

DDP chemoresistance

[53]

LUAD

circSETDB1

miR-7/Sp1

Invasion, EMT

[78]

circ_0102537

VEGF

Invasion, metastasis

[77]

SCLC

FECR1

miRNA584-ROCK1

Resistance

[42]

Ovarian cancer

circ-0001068

miR-28-5p

Inducer of PD1 expression

[81]

circRNA051239

miR-509-5p/PRSS3

Proliferation, metastasis

[32]

circPUM1

miRNA-615-5p, miRNA-6753-5p

Invasion, metastasis

[43]

circWHSC1

miRNA-1182, miRNA-145

Invasion, metastasis

[44]

circCdr1as

miRNA-1270

Resistance

[56]

GC

circSHKBP1

miR-582-3p/HUR/VEGF

Progression

[69]

circ_0032821

miR-515-5p/SOX9

OXA resistance

[49]

circNEK9

miR-409-3p/MAP7

Proliferation, invasion, metastasis

[28]

circNRIP1

miRNA-149-5p/AKT1/mTOR

Proliferation

[29]

circRanGAP1

miRNA-877-3p/VEGFA

Invasion, metastasis

[40]

ciRS-133

miRNA-133/PRDM16

Invasion, metastasis

[123]

Prostate cancer

circ_0044516

miR-29a-3p

Proliferation, metastasis

[31]

circ_0044516

miRNA-29a-3p

Proliferation, metastasis

[31]

UCB

circPRMT5

miRNA-30c/SNAIL1/E-cadherin

Invasion, metastasis

[41]

RCC

circ_400068

miR-210-5p/SOCS1

Proliferation

[112]

cSCC

circ-CYP24A1

CDS2, MAVS, SOGA

Proliferation, invasion, metastasis

[82]

OS

hsa_circ_103801

multidrug resistance-associated protein 1 and P-glycoprotein

Cisplatin resistance

[57]

MM

circMYC

many signal pathway transductions

Recurrence, bortezomib resistance

[83]

AML

circ_0009910

miR5195-3p/GRB10

Proliferation, cell cycle, apoptosis

[30]