Roles and clinical application of exosomal circRNAs in the diagnosis and treatment of malignant tumors

Table 1 Role of exosomal circRNAs in diagnosis and prognostic assessment of malignant tumors

Tumor type	circRNA(s)	Expression level	Role(s)	References
HCC	circRNA-CDYL	Up	Diagnosis	[3]
LSCC	circ_0019201	Up	Diagnosis	[62]
	circ_0011773	Up	Diagnosis	[62]
	circ_0122790	Up	Diagnosis	[62]
ESCC	circ_0026611	Up	Prognosis	[63]
	circ-0048117	Up	Prognosis	[64]
	circ_0001946	Up	Prognosis	[65]
CRC	circ_0004771	Up	Diagnosis	[67]
CRC	circHIPK3	Up	Diagnosis	[68]
GC	circSHKBP1	Up	Diagnosis and prognosis	[69]
GC	circ_0065149	Down	Diagnosis	[70]
HCC	circ_0004001	Up	Diagnosis	[71]
	circ_0004123	Up	Diagnosis	[71]
	circ_0075792	Up	Diagnosis	[71]
	circ_0051443	Down	Diagnosis and prognosis	[72]
PDAC	circ-PDE8A	Up	Diagnosis and prognosis	[39]
NSCLC	circRNA_102481	Up	Diagnosis	[73]
NSCLC	circFARSA	Up	Diagnosis and prognosis	[74]
SCLC	FECR1	Up	Diagnosis and prognosis	[42]
LUAD	circ_002178	Up	Diagnosis	[75]
	circ_0001492	Up	Diagnosis	[76]
	circ_0001346	Up	Diagnosis	[76]
	Circ_0102537	Up	Diagnosis and prognosis	[77]
	circSETDB1	Up	Diagnosis and prognosis	[78]
Breast carcinoma	circ_00005795	Up	Diagnosis and prognosis	[79]
Breast carcinoma	circ_0088088	Up	Diagnosis and prognosis	[80]
Ovarian cancer	Circ-0001068	Up	Diagnosis	[81]
cSCC	circ-CYP24A1	Up	Diagnosis	[82]
MM	circMYC	Up	Diagnosis and prognosis	[83]
Glioma	circNFIX	Up	Prognosis	[84]
Glioma	circ-HIPK3	Up	Diagnosis	[85]

HCC hepatocellular carcinoma; LSCC laryngeal squamous cell carcinoma; ESCC esophageal squamous cell carcinoma; CRC colorectal cancer; HCC hepatocellular carcinoma; PDAC pancreatic ductal adenocarcinoma; NSCLC non-small cell lung cancer; LUAD lung adenocarcinoma; SCLC small-cell lung cancer; GC gastric cancer; cSCC cutaneous squamous cell carcinoma; MM multiple myeloma

ISSN: 1479-5876