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Table 2 Inferred tumor relatedness and origin for the 16 patients with lung-specific cancer of unknown primary

From: A molecular approach integrating genomic and DNA methylation profiling for tissue of origin identification in lung-specific cancer of unknown primary

Patient ID

Time lag between tumors

Tumor location

Primary vs. metastatic lesions

CGP-methylation concordance

Per CGP analysis

Per DNA methylation analysis

Methyl score

1

Synchronous

Lung

P

P

0.475

Y

Colon

M

M

0.378

2

Metachronous

Lung

M

M

0.537

Y

Stomach

P

P

0.634

3

Metachronous

Lung

P

P

0.393

Y

Stomach

M

M

0.354

4

Synchronous

Lung

P

P

0.349

Y

Colon

M

M

0.391

7

Metachronous

Lung

M

M

0.695

Y

Cervix

P

P

0.666

10

Metachronous

Lung

M

M

0.715

Y

Cervix

P

P

0.713

12

Metachronous

Lung

P

P

0.259

Y

Colon

P

P

0.647

13

Synchronous

Lung

P

P

0.289

Y

Cervix

P

P

0.548

14

Metachronous

Lung

P

P

0.249

Y

Colon

P

P

0.797

5

Synchronous

Lung

Inconclusive

M

0.531

/

Stomach

P

0.720

6

Synchronous

Lung

Inconclusive

P

0.297

/

Colon

M

0.652

8

Synchronous

Lung

Inconclusive

M

0.575

/

Colon

P

0.554

9

Synchronous

Lung

Inconclusive

P

0.491

/

Colon

M

0.455

15

Synchronous

Lung

Inconclusive

P

0.428

/

Stomach

P

0.556

11

Synchronous

Lung

P

Not available

/

Y

Stomach

P

P

0.751

16

Synchronous

Lung

P

Not available

/

/

Cervix

M

Not available

/