Fig. 2

Tumor clonality and origin inferred from comprehensive genomic profiling (CGP) and inter-tumor time interval. A A heatmap showing the number of total genomic alterations identified in a tumor (in the form of row or column sum) and the number of those shared by the corresponding tumor pairs. T1 refers to intrathoracic tumors and T2 extrathoracic ones. B–D Profiles of genomic alterations for patients classified into three classes: B unambiguous TOO inference enabled by CGP alone, C unambiguous TOO inference enabled by CGP and inter-tumor time lag, and D inconclusive cases. All samples were microsatellite stable (MSS) except for the colon tumor of P12, which was microsatellite unstable (MSI)