Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer

Table 2 Cox regression analysis of p-ATF1-T184 and MMP2 in gastric cancer with overall survival

Characteristics	HR	CI (95%)	P value
Univariate Cox regression analysis
P-ATF1-T184	2.399	1.244–4.628	0.009*
MMP2	1.951	1.026–3.708	0.041*
P-ATF1-T184 and MMP2	2.624	1.388–4.959	0.003*
Sex	0.719	0.378–1.367	0.314
Age	0.682	0.266–1.747	0.426
Degree of infiltration	24.011	0.271–2.127 × 103	0.165
Lymph node metastasis	5.018	1.543–16.325	0.007*
Distant metastasis	5.621	2.623–12.046	< 0.001*
Tumor size	1.478	0.750–2.914	0.259
Differentiation	0.617	0.283–1.345	0.225
Multivariate Cox regression analysis
P-ATF1-T184	1.712	0.872–3.360	0.118
Lymph node metastasis	3.671	1.102–12.225	0.034*
Distant metastasis	3.992	1.843–8.674	< 0.001*
Multivariate Cox regression analysis
MMP2	1.691	0.868–3.292	0.122
Lymph node metastasis	3.875	1.163–12.787	0.027*
Distant metastasis	4.250	1.955–9.239	< 0.001*
Multivariate Cox regression analysis
P-ATF1-T184 and MMP2	2.359	1.227–4.533	0.010*
Lymph node metastasis	3.640	1.095–12.095	0.035*
Distant metastasis	4.502	2.066–9.812	< 0.001*

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