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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Phosphorylated ATF1 at Thr184 promotes metastasis and regulates MMP2 expression in gastric cancer

Fig. 4

P-ATF1-T184 influences the DNA binding activity and stability of ATF1. A ChIP experiment showed the influence of ATF1-T184D and ATF1-T184A on DNA binding ability of MMP2 in HEK293 cells. B Luciferase reporter assays showed p-ATF1-T184 promoted the activity of MMP2 promoter. C The invasion capabilities of p-ATF1-T184 were impaired by MMP2 knockdown in BGC823 cells. D Cycloheximide experiment showed effect of p-ATF1-T184 on the stability of ATF1 protein in MGC803

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