Table 5 Effect of each parameter on DCR according to baseline values and to the variation between T1 value (after 1 month of therapy) and T0 value (baseline value). This difference has been indicated as delta value (Δ)
Parameter | Univariate | Two-variable | Multivariablea | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Variable | Timepoint | Value | p | OR | Lower OR | Upper OR | p | OR | Lower OR | Upper OR | p | OR | Lower OR | Upper OR |
Platelets | Basal | + 10,000 | 0.077 | 1.027 | 0.997 | 1.058 | – | – | – | – | ||||
Δ | Ref ≤ 25,000 | 0.043 | 1.749 | 1.019 | 3.001 | – | – | – | – | |||||
White blood cell count | Basal | + 100 | 0.002 | 1.017 | 1.006 | 1.028 | – | – | – | – | ||||
Δ | Ref ≤ 1920 | < 0.001 | 4.136 | 1.927 | 8.878 | 0.003 | 3.422 | 1.528 | 7.666 | |||||
Neutrophils | Basal | + 100 | < 0.001 | 1.030 | 1.015 | 1.044 | 0.004 | 1.022 | 1.007 | 1.037 | ||||
Δ | Ref ≤ 310 | 0.021 | 1.850 | 1.097 | 3.120 | – | – | – | – | |||||
Lymphocytes | Basal | + 100 | 0.381 | 0.987 | 0.957 | 1.017 | – | – | – | – | ||||
Δ | Ref ≥ − 300 | 0.002 | 2.621 | 1.444 | 4.756 | 0.074 | 1.804 | 0.944 | 3.446 | |||||
NL ratio | Basal | + 1 | < 0.001 | 1.329 | 1.127 | 1.568 | – | – | – | – | ||||
Δ | Ref ≤ 0.86 | 0.001 | 2.779 | 1.503 | 5.140 | – | – | – | – | |||||
PL ratio | Basal | + 1 | 0.086 | 1.003 | 1.000 | 1.006 | – | – | – | – | ||||
Δ | Ref ≤ 22.85 | 0.009 | 2.022 | 1.191 | 3.432 | – | – | – | – | |||||
Age | Basal | + 1 | 0.879 | 1.001 | 0.983 | 1.020 | – | – | – | – | ||||
Sex | Basal | Ref F | 0.507 | 0.845 | 0.514 | 1.389 | – | – | – | – | ||||
Number of metastatic sites | Basal | Ref ≥ 3 | 0.010 | 0.519 | 0.316 | 0.853 | – | – | – | – | ||||
LDH | Basal | Ref elevated | 0.002 | 0.419 | 0.243 | 0.722 | 0.032 | 0.528 | 0.295 | 0.946 | ||||