Table 4 Effect of each parameter on OS according to baseline values and to the variation between T1 value (after 1 month of therapy) and T0 value (baseline value). This difference has been indicated as delta value (Δ)

Platelets

Basal

 + 10,000

1.020

1.001

1.039

–

–

–

–

Δ

Ref ≤ 25,000

1.512

1.063

2.151

–

–

–

–

White blood cell count

Basal

 + 100

1.009

1.005

1.013

–

–

–

–

Δ

Ref ≤ 1920

3.246

2.171

4.854

 < 0.001

2.918

1.882

4.526

Neutrophils

Basal

 + 100

1.014

1.010

1.018

 < 0.001

1.011

1.005

1.016

Δ

Ref ≤ 310

1.880

1.330

2.659

–

–

–

–

Lymphocytes

Basal

 + 100

0.977

0.955

0.999

–

–

–

–

Δ

Ref ≥ -300

2.319

1.578

3.409

0.038

1.627

1.028

2.576

NL ratio

Basal

 + 1

1.279

1.169

1.400

–

–

–

–

Δ

Ref ≤ 0.86

2.908

2.012

4.202

–

–

–

–

PL ratio

Basal

 + 1

1.003

1.001

1.005

0.022

1.003

1.000

1.005

Δ

Ref ≤ 22.85

2.019

1.429

2.853

0.140

1.378

0.901

2.109

Age

Basal

 + 1

0.255

1.008

0.994

1.021

–

–

–

–

Sex

Basal

Ref F

0.282

0.829

0.589

1.166

–

–

–

–

Number of metastatic sites

Basal

Ref ≥ 3

0.089

0.746

0.532

1.046

–

–

–

–

LDH

Basal

Ref elevated

 < 0.001

0.395

0.276

0.564

 < 0.001

0.499

0.344

0.724