Fig. 3

OS probability at 145 months by neutrophils and PLR at baseline. All patients have been clustered in 4 groups, according to the combination of the values of the dichotomized variables basal LDH and ΔWBC, then associated with the values of the continuous variables baseline neutrophils (a) and baseline PLR (b). Multivariable analysis results show a correlation between higher baseline WBC or neutrophils and lower OS. Risk of progression increases with increasing baseline neutrophils, more in those patients with risk factors (elevated LDH at baseline and elevated ΔWBC) than in patients with more favourable risk factors (ΔWBC < 1920/mm³ and normal LDH at baseline). b Risk of progression increases with increasing baseline PLR, more in those patients with risk factors (elevated LDH at baseline and elevated ΔNLR) than in patients with more favourable risk factors (ΔWBC < 1920/mm³ and normal LDH at baseline)