Fig. 2

PFS probability at 80 months by Neutrophils, and WBC at baseline. All patients have been clustered in 4 groups, according to the combination of the values of the dichotomized variables basal LDH and ΔNLR, then associated with the values of the continuous variables baseline neutrophils (a) and baseline WBC count (b). Multivariable analysis results show a correlation between higher baseline neutrophils or WBC and progression. Risk of progression increases with increasing baseline neutrophils, more in those patients with risk factors (elevated LDH at baseline and elevated ΔNLR) than in patients with more favourable risk factors (ΔNLR < 0.86 and normal LDH at baseline). Risk of progression increases with increasing baseline WBC, more in those patients with risk factors (elevated LDH at baseline and elevated ΔNLR) than in patients with more favourable risk factors (ΔNLR < 0.86 and normal LDH at baseline)