Fig. 7

Compounds with significant correlations of drug sensitivity with DEPTH2 scores in cancer cell lines and their target pathways. A Of 265 antitumor compounds from the Genomics of Drug Sensitivity in Cancer (GDSC) project (https://www.cancerrxgene.org), 131 show a significant inverse correlation of IC50 values with DEPTH2 scores versus 68 showing a significant positive correlation (Spearman correlation, P < 0.05). The compounds whose IC50 values have a correlation of |ρ| > 0.3 with DEPTH2 scores are given. B The pathways having significant correlations of enrichment scores with DEPTH2 scores and being targeted by the compounds with significant correlations of drug sensitivity (IC50 values) with DEPTH2 scores in cancer cell lines. The Spearman correlation coefficients (ρ) and P-values are shown