Fig. 2

DEPTH2 ITH correlating with unfavorable clinical outcomes in cancer. A Kaplan–Meier curves showing that higher-DEPTH2-score (> median) tumors have more inferior survival than lower-DEPTH2-score (< median) tumors in pan-cancer. The log-rank test P-values are shown. OS: overall survival, DSS: disease-specific survival, PFI: progression-free interval, DFI: disease-free interval. B DEPTH2 scores are significantly higher in advanced versus non-advanced [metastatic versus primary, late-stage (stage III–IV) versus early-stage (stage I–II), and high-grade (G3–4) versus low-grade (G1–2)] tumors in diverse cancers (one-tailed Mann–Whitney U test, P < 0.05). C Significant positive correlations between DEPTH2 scores and tumor stemness scores in pan-cancer and in 15 individual cancer types (Spearman correlation, P < 0.05). D Comparisons of DEPTH2 scores among cancer subtypes. K–W test, Kruskal–Wallis test; U test, Mann–Whitney U test. *P < 0.05, **P < 0.01, ***P < 0.001