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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Dysfunctional bone marrow endothelial progenitor cells are involved in patients with myelodysplastic syndromes

Fig. 4

Regulatory abilities of BM EPCs from MDS patients to differentiate T cells. A Schematic diagram of the study design for BM EPC coculture processes with T cells. After 3 days of coculture, the differentiation of T cells was analysed by flow cytometry. B The subtypes of Th1 cells, Th2 cells, Th17 cells and Tregs were characterized by positive expression of CD4+IFN-γ+, CD4+IL-4+, CD4+IL-17+ and CD4+CD25+Foxp3+, respectively. The percentage of C Th1 cells, D Th17 cells, E Th2 cells, F Tregs and G the ratio of Th1/Th2 cells after coculture without (Control) or with HD-derived, L-MDS, H-MDS, AML patient-derived BM EPCs for 3 days. The paired analyses were using Wilcoxon matched-pairs signed rank test. Data are presented as the means ± SEM (*P ≤ 0.05, **P ≤ 0.005). AML Acute myeloid leukaemia, BM Bone marrow, BMMNCs Bone marrow mononuclear cells, EPCs Endothelial progenitor cells, HD Healthy donor, H-MDS Higher-risk myelodysplastic syndromes, L-MDS Lower-risk myelodysplastic syndromes, Th T helper, Tregs Regulatory T cells, ROS reactive oxygen species

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