Fig. 7
From: The SETD8/ELK1/bach1 complex regulates hyperglycaemia-mediated EndMT in diabetic nephropathy
Overexpression of SETD8 ameliorated the pathological process in rats with DN. a Western blot results of genes in different rat groups. b–h mRNA expression of genes in different rat groups. (n = 5/group). i–k Immunostaining of different genes in the kidneys of rats with the corresponding treatments. Hyperglycaemia-induced upregulation of ELK1 and bach1 can be reversed by AVV-SETD8 overexpression (n = 10/group). (Data are presented as the mean ± standard deviation, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, statistical analysis was carried out by one-way ANOVA.)