Optimizing NK-92 serial killers: gamma irradiation, CD95/Fas-ligation, and NK or LAK attack limit cytotoxic efficacy

Table 2 Primary blood NK and LAK killing of NK-92 cells at 4 h

NK activation state	Donor #	E:T (PBMC:NK-92)	⁵¹Cr 'Target' cells⁺
NK activation state	Donor #	E:T (PBMC:NK-92)	Non-irradiated NK-92	10 Gy irradiated NK-92	K562
Unstimulated	SC-0394	107:1	7%*	15%	76%
	SC-3663	33.5:1	2%*	6%*	23%
	SC-6617	60:1	8%*	19%	13%
	SC-0975	48:1	7%*	12%	11%
IL-2 LAK	SC-0394	23:01	8%*	ND	96%
	SC-3663	15.2:1	1%*	4%*	47%
	SC-6617	55:1	17%	31%	78%
	SC-0975	42:1	27%	43%	82%

⁺%Specific Release. Data are available in Additional file 4: Fig. S2 for the E:T titrations
^*Indicates cytotoxicity below the positive killing threshold of 10%

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