Fig. 4

Serum Ang-2 levels. Serum Ang-2 levels were measured in the PAT study cohort (a) and in a second validation cohort (b). Levels are depicted as the median (IQR) of the fold change (FC) compared to that in HCs, as the standard was 1.5-fold higher in the ELISA of the ^nd validation cohort compared to the PAT study cohort. For statistical analysis, the Kruskal–Wallis with Dunn´s post-hoc multiple comparisons test was used. P values ≤ 0.05 were considered statistically significant. [Ang-2 = Angiopoietin-2; IQR = interquartile range; RH-PAT = reactive hyperaemia peripheral arterial tonometry]