Fig. 3

Serum ET-1 concentrations. The serum ET-1 concentrations were measured in the PAT study cohort (a) and in a second validation cohort (b). The median (IQR) serum ET-1 concentration is shown. For statistical analysis, the Kruskal–Wallis with Dunn´s post-hoc multiple comparisons test was used. P values ≤ 0.05 were considered statistically significant. ET-1 Endothelin-1; IQR interquartile range; RH-PAT reactive hyperaemia peripheral arterial tonometry