Table 4 Correlation of PD1 expression by TAMs with clinicopathological characteristics of ICCs

Gender

 Male

 Female

Age(years)

 ≥ 60

 < 60

ECOG PS

 0

 1

Size of primary tumor (cm)

 ≥ 5

 < 5

Histopathological grading

 Low

 Intermediate to high

TNM stage

 I + II

 III

Lymph node invasion

 Yes

 No

Microvascular invasion

 Yes

 No

HBV

 Yes

 No

HCV

 Yes

 No

Liver cirrhosis

 Yes

 No

Child–Pugh grade

 A

 B

CEA (ng/mL)

 ≥ 10

 < 10

CA199(U/mL)

 ≥ 60

 < 60

CA724(U/mL)

 ≥ 14

 < 14

ALT(U/L)

 ≥ 80

 < 80

AST(U/L)

 ≥ 70

 < 70

Total bilirubin (umol/L)

 ≥ 42

 < 42

Direct bilirubin (umol/L)

 ≥ 16

 < 16

Indirect bilirubin (umol/L)

 ≥ 30

 < 30