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Table 2 Correlation of CD68 expression by TAMs with clinicopathological characteristics of ICCs

From: SIRPα and PD1 expression on tumor-associated macrophage predict prognosis of intrahepatic cholangiocarcinoma

Characteristics (No. of patients)

CD68 hi

CD68 low

P-value

Gender

   

 Male

30

17

 

 Female

20

14

0.647

Age(years)

   

 ≥ 60

20

18

 

 < 60

30

13

0.113

ECOG PS

   

 0

23

14

 

 1

27

17

0.941

Size of primary tumor (cm)

   

 ≥ 5

3

4

 

 < 5

47

27

0.282

Histopathological grading

   

 Low

24

13

 

 Intermediate to high

26

18

0.594

TNM stage

   

 I + II

26

28

 

 III

24

3

0

Lymph node invasion

   

 Yes

14

2

 

 No

36

29

0.018

Microvascular invasion

   

 Yes

16

1

 

 No

34

30

0.002

HBV

   

 Yes

18

2

 

 No

32

29

0.003

HCV

   

 Yes

1

1

 

 No

49

30

0.73

Liver cirrhosis

   

 Yes

4

6

 

 No

46

25

0.131

Child–Pugh grade

   

 A

4

10

 

 B

46

21

0.005

CEA (ng/mL)

   

 ≥ 10

4

3

 

 < 10

46

28

0.794

CA199(U/mL)

   

 ≥ 60

36

26

 

 < 60

14

5

0.138

CA724(U/mL)

   

 ≥ 14

35

20

 

 < 14

15

11

0.607

ALT(U/L)

   

 ≥ 80

37

19

 

 < 80

13

12

0.229

AST(U/L)

   

 ≥ 70

30

20

 

 < 70

20

11

0.684

Total bilirubin (umol/L)

   

 ≥ 42

44

25

 

 < 42

6

6

0.365

Direct bilirubin (umol/L)

   

 ≥ 16

46

26

 

 < 16

4

5

0.258

Indirect bilirubin (umol/L)

   

 ≥ 30

33

16

 

 < 30

17

15

0.198