Table 4 Summary of studies of the mechanism of action of miRNAs in the treatment of AP and its complications
From: New challenges for microRNAs in acute pancreatitis: progress and treatment
miRNA | Mechanism | Disease type | Application | Animal model | References |
|---|---|---|---|---|---|
miR-148a | Inhibits the production of the autophagy-related proteins LC3-II, Beclin1, ATG4c and ATG7 via the IL-6/STAT3 signalling pathway | AP | Suppress | Male BALB/c mice | [10] |
miR-92b-3p | Suppresses the expression of proteins associated with the MKK3-p38 signalling pathway (p-MKK3, MKK3, p-p38 and p38) by reducing TRAF3 production | AP | Suppress | – | [59] |
miR-399-3p | Inhibits the production of inflammatory and apoptotic factors by regulating TRAF3 | AP | Suppress | – | [82] |
miR-802 | Inhibits ADM production and acinar cell proliferation | AP | Suppress | mir-802 fl/fl mice | [83] |
miR-181b | Inhibits autophagy and increases apoptosis by regulating mTOR/Akt when combined with PNS | AP | Suppress | Male Sprague- Dawley rats | [87] |
miR-216b | Inhibition of the MAP2K6/p38 pathway when combined with QE | AP | Suppress | C57BL/6 mice | [88] |
miR-15a | Combined with baicalin to regulate the MAP2K4/JKN signalling pathway | AP | Suppress | – | [65] |
miR-9 | Infusion of miR-9-modified BMSCs induces angiogenesis to repair damaged pancreatic tissue | AP | Suppress | Male SD rats | |
miR-181a-5p | Regulation of PTEN/Akt/TGF-β1 via secretion of miR-181a-5p from BMSCs | AP | Suppress | Male SD rats | [93] |
miR-339-3p | Inhibition of Akt/mTOR signaling by targeting Anxa3 | AP with lung injury | Suppress | Male mice | [94] |
miR-542-5p | Inhibits the PAK1/MAPK signalling pathway and reduces the release of inflammatory factors | AP with lung injury | Suppress | Mice | |
miR-21-3p | Promotes the release of serum amylase, lipase, and inflammatory factors and inhibits pulmonary oxygenation by activating the TRP signalling pathway | AP with lung injury | Promote | Wistar rats | [97] |
miR-214-3p | Promotion of pancreatic acinar degeneration and renal tubular epithelial cell swelling via the PTEN/Akt axis | AP with kidney injury | Promote | Male Sprague–Dawley rats | [98] |
miR-122 | AP promotes the secretion of miR-122 and reduces the level of renal EPO | AP with kidney injury | Promote | C57BL/6 mice | [99] |
miR-216a, miR-29a, miR-324-5p | Predicts the severity of liver damage | AP with liver injury | Promote | – | [100] |