Table 2 Summary of studies of related miRNAs and their functional roles in the AP process

miR-9

FGF10/NF-κB

Inhibits expression of the inflammatory factors IL-1β, IL-6 and TNF-α, as well as the apoptosis factors Bax and cl-caspase 3/9

In vitro

[35]

miR-668, miR-3594-3p, miR-24-3p, miR-483-5p, miR-3541

TRAF6-TAB2-TAK1-NIK/IKK-NF-κB pathway

Activates macrophages and promotes IL-1β, IL-6 and TNF-α production

In vitro

[43]

miR-216a

Akt and TGF-β Pathway

Promotes TNF-α and IL-6 production

Both

[36]

miR-30a-5p

HTRA/TGF-β1

Inhibits the production of trypsin, amylase and the inflammatory factors TNF-α, IL-6 and IL-1β

Both

[47]

miR-155

SOCS1

Promotes Th17 cell production and IL-6, IL-13 and TNF-α expression

Both

[51]

miR-361-5p

NFIA and Hes1

Promotes Th17 cells to secrete IL-17A

Both

[52]

miR-29a/b1

–

Promotes infiltration of neutrophils and macrophages and release of IL-6, IL-10 and TGFβ1

In vivo

[53]

miR-155

TAB2

Promote the production of Beclin-1 and LC3 II levels and worsens the degree of autophagy damage

In vivo

[58]

miR-92b-3p

TRAF3/MKK3-p38

Increases levels of Beclin-1, LC3 II and autophagosome formation

In vitro

[59]

miR-21

Caspase 8

Upregulation of RIP1 and RIP3 expression promotes necrosome formation

In vivo

[63]

miR-19b

–

Promotes necrosis of pancreatic acinar cells

In vivo

[64]

miR-15a

MAP2K4/JKN

Inhibits the production of IL-1, TNF and IL-6 and reduces pancreatic tissue necrosis

Both

[65]