Table 1 Summary of studies of miRNAs that affect the production of inflammatory cells and inflammatory factors
From: New challenges for microRNAs in acute pancreatitis: progress and treatment
miRNAs | Expression | Targets | Effect on inflammation | Inflammation-related cells or factors | References |
|---|---|---|---|---|---|
miR-let-7a/let-7d/let-7f | Up | Tet2, Lin28a/Sdha axis | Promotion | Macrophages, IL-6 | [17] |
microRNA let-7 | Up | A20 | Promotion | Macrophages, TNF, IL-1β | [18] |
miR-93 | Up | TLR4/NF-κB | Suppression | TNF-α, IL-6, IL-1β | [19] |
miR-21 | Down | PDCD4/NF-κB | Suppression | Macrophages, TNF-α、IL-6 | [20] |
miR-34a | Up | KLF4 | Promotion | Macrophages, TNF-α, IL-6, IL-1β, and MCP-1 | [21] |
miR-27a | Down | TLR4/MyD88/NF-κB | Promotion | TNF-α, IL-6, IL-1β | [22] |
miR-200a | Down | Keap1/Nrf2 | Promotion | TNF-α, L-1β | [23] |
miR-495-3p | Up | IL5RA | Promotion | TNF-α | [24] |
miR-124- 3p | Down | p65 | Promotion | TNF-α, IL-6, IL-1β | [25] |
miR-138 | Up | VEGF/NF-κB | Suppression | TNF-α, IL-1β, IL-6 and IL-18 | [26] |
miR-342-3p | Up | Rictor | Suppression | Foxp3+ Regulatory T cells IL-17、IFN-γ and TNF-α | [27] |
miR-873a-5p | Up | NF-κB | Suppression | TNF-α, IL-1β, INOS and IL-6 | [28] |
miR-146a | Up | TLR4/NF-κB | Suppression | TNF-α, IL-6, IL-8 and IL-1 β | [29] |
miR-542-3p | Up | TLR4 | Suppression | TNF-α, IL-6 and MCP-1 | [30] |
miR-193b-3p | Up | HDAC3/NF-κB p65 | Suppression | IL-1β, IL-6 and TNF-α | [31] |
miR-140-5p | Up | HMGB1/PI3K/AKT | Suppression | TNF-α, IL-6, MMP1 and MMP3 | [32] |
miR-27a-3p | Up | FOXO3/NAPDH/ROS | Suppression | IL-6, IL-8 | [33] |